Research in our lab focuses on various aspects of drug delivery - from vehicle design to particle behavior in blood flow to targeting kinetics. The lab is fitted with almost all the necessary tools and equipment required for our work and we have access to specialized resources on campus including research facilities in the Cardiovascular Center on the medical campus, nanofabrication labs and scanning electron microscope use in the Electrica Engineering Department, as well as additional instrument access in the Biomedical and Chemical Engineering Departments.
Location, Parking, and Bus Routes
Our lab is located on the third floor of the G.G. Brown Building on the engineering (North) campus of the University of Michigan.
G.G. Brown Building (Google Map, U-M Building Search, North Campus Map)
There are parking lots available nearby all along Hayward St (most require student permits):
- NC48 - Blue Permit, Visitor (Red) Metered parking (west on Hayward)
- NC46 - Orange Permit (east on Hayward)
- NC26 - Visitor (Red) Metered parking (east on Hayward)
- NC53 - Yellow/Orange Permit (east on Hayward)
The North Commuter and Northwood Blue Michigan buses regularly run by Hayward and Beal to our east; the #22 and #1 Ann Arbor Transportation Authority (AATA) routes also run by the same intersection.
Biosafety Hood - Labconco Purifier Class II Biosafety Cabinet
- Our lab performs mammalian cell culture, primary cell isolation, and other techniques that require a sterile environment.
- We have a dedicated biosafety hood that we use for umbilical vein cell isolation.
- Many of our particle fabrication methods require use of volatile chemicals.
- The fume hood in our lab also houses our high speed stir machines.
Flow Cytometer - Beckman Coulter Quanta SC
- Our lab has the only flow cytometer on all of North Campus - we regularly use this machine for typical cell protein/expression measurements and to determine the characteristics of our fabricated particles.
Microscopes - Nikon Eclipse TE2000-S BrightField Inverted Microscopes
- There are two main microscope stations that we utilize to study particle behavior in blood flow; one of these microscopes is fitted with a humidified incubator and a UV light source for immunofluorescence assays.
- We also have a third microscope used for general observations.
Modified External Humidified Incubator
- Our modified external humidified incubator fits around one of our Nikon microscopes with fluorescent imaging capabilities.
- Here, we use flow chambers and other setups to study the flow of particles in blood solutions.
- There are two Eppendorf centrifuges in our lab
Incubators and Water Baths
- We have two incubators, one dedicated for experiments and the other for continued cell culture (yes, these pictures are rotated).
- We also have two water baths usually maintained at 56C and 37C.
- We have a small water-bath/immersion sonicator that we use to clean our instruments.
Oven and Autoclave and DI H2O Access
- Our lab has access to two different autoclaves which provide us with the ability to sterilize glassware and other instruments as well as biohazardous waste.
- We also have access to a reliable source of purified DI H2O in the nearby Linderman lab.
- We also have two different ovens - one for baking glassware and one for experiments.
Refrigerators, Freezers, and Liquid Nitrogen Storage
- There are four (4) refrigerators in our lab - two at 4C and two at -20C.
- We also have a freezer housed in a separate room that maintains antibodies and longer-term storage items at -40C.
- We also have a liquid nitrogen storage tank where we keep our cell lines (mammalian).
Pictures to be added!