department of chemical engineering @ the university of michigan












Laboratory for Quantitative Signaling and Multi-scale Modeling

Welcome to the Linderman Group webpage!
We apply chemical engineering principles to the field of biology and medicine. Our research is focused on fundamental studies in cell biology and cellular signal transduction, which has a myriad of applications including drug discovery and tissue engineering.

Research Areas
A multi-scale and multi-system approach to understand granuloma formation in TB Models of receptor dynamics, signal transduction, and cell responses Agent-based modeling of chemotaxis, drug distribution, and vascularization in the tumor microenvironment
Recent Media Coverage

Check out an article featuring us written in American Society for Microbiology titled How Computer Scientists are Setting the Stage to End Tuberculosis.

We were featured by Michigan Engineering in an article titled Peering into the black box of tuberculosis!

Dr. Elsje Pienaar was featured in an article titled Fighting tuberculosis!

Recent News
May 2018
Check out Elsje's new paper, Emergence and selection of isoniazid and rifampin resistance in tuberculosis granulomas, published in PLoS ONE.

May 2018
Patrick passed his Doctoral Candidacy Exam, and Louis passed his Preliminary Exam. Congratulations on becoming PhD Candidates!

November 2017
Check out Phillip's new paper, The CXCL12/CXCR7 signaling axis, isoforms, circadian rhythms, and tumor cellular composition dictate gradients in tissue, published in PLoS ONE.

October 2017
At the 2017 Biomedical Engineering Society Annual Meeting in Phoenix, AZ, Bruna presented a poster on her research, and Joseph and Phillip had oral presentations.

October 2017
Patrick Kinnunen is new pre-doctoral candidate in our group. Welcome Patrick!

August 2017
Check out Joseph's new paper, Applying Optimization Algorithms to Tuberculosis Antibiotic Treatment Regimens, published in Cellular and Molecular Bioengineering.

August 2017
Dr. Elsje Pienaar is starting her new faculty position at the Weldon School of Biomedical Engineering at Purdue University. Check out her research webpage here. Congratulations!

July 2017
Two new postdoctoral scholars have joined our group: Dr. Caitlin Hult and Dr. Timothy Wessler. Welcome to Tim and Caitlin!

May 2017
A new bioinformatics graduate student, Louis Joslyn, has joined our group. Welcome Louis!

February 2017
Dr. Mohammad Fallahi-Sichani, a 2011 PhD alum from our group, is starting his faculty position in the BME department here at the University of Michigan. Welcome back Mohammad!

January 2017
Check out Madhuresh's new paper, New insights into mammalian signaling pathways using microfluidic pulsatile inputs and mathematical modeling , published in Integrative Biology.

October 2016
Dr. Linderman received a new NIH grant to study TB!

September 2016
Both Joey and Bruna are PhD Candidates! Congratulations!

August 2016
Madhuresh successfully defended his PhD Thesis titled Information Processing under Physiological Pulsatile Stimulation in a G-protein Coupled Signaling Pathway. Congratulations Madhuresh!

April 2016
Check out Elsje's new paper, Multi-scale model of Mycobacterium tuberculosis infection maps metabolite and gene perturbations to granuloma sterilization predictions, published in Infection and Immunity.

January 2016
Check out Cordelia's new paper, Strategic Priming with Multiple Antigens can Yield Memory Cell Phenotypes Optimized for Infection with Mycobacterium tuberculosis: A Computational Study, published in Frontiers in Microbiology.

November 2015
Check out Elsje's new paper, In silico evaluation and exploration of antibiotic tuberculosis treatment regimens, published in BMC Systems Biology.

September 2015
Check out Madhuresh's new paper, Temporal Modulation of a GPCR Pathway Elucidates Band-Pass Processing for the Downstream Signaling and Transcription Factor Activation, that made the cover of Integrative Biology.

April 2015
Check out Elsje's new paper, A multi-scale approach to designing therapeutics for tuberculosis, published in Integrative Biology.

March 2015
Laura successfully defended her PhD thesis titled Mechanistic and Statistical Models to Understand CXCL12/CXCR4/CXCR7 in Breast Cancer. Congratulations Laura!