department of chemical engineering @ the university of michigan












Laboratory for Quantitative Signaling and Multi-scale Modeling

Welcome to the Linderman Group webpage!
We apply chemical engineering principles to the field of biology and medicine. Our research is focused on fundamental studies in cell biology and cellular signal transduction, which has a myriad of applications including drug discovery and tissue engineering.

Research Areas
A multi-scale and multi-system approach to understand granuloma formation in TB Models of receptor dynamics, signal transduction, and cell responses Agent-based modeling of chemotaxis, drug distribution, and vascularization in the tumor microenvironment
Recent Media Coverage

Check out an article featuring us written in American Society for Microbiology titled How Computer Scientists are Setting the Stage to End Tuberculosis.

We were featured by Michigan Engineering in an article titled Peering into the black box of tuberculosis!

Dr. Elsje Pienaar was featured in an article titled Fighting tuberculosis!

Recent News
February 2019
Joseph was awarded the Rackham Predoctoral Fellowship, given to doctoral students in the final year of PhD. Congratulations!

January 2019
Patrick was a member of a winning team at the data hackathon MDataHack 2019. Congratulations Patrick!

January 2019
Louis attended the Keystone Symposium, Tuberculosis: Mechanisms, Pathogenesis and Treatment, and presented a poster on his tuberculosis vaccine research.

October 2018
At the 2018 Biomedical Engineering Society Annual Meeting in Atlanta, GA, Bruna presented a poster on her research, and Joseph had an oral presentation.

August 2018
Check out Louis's new paper, Integrating Non-human Primate, Human, and Mathematical Studies to Determine the Influence of BCG Timing on H56 Vaccine Outcomes, published in Frontiers in Microbiology.

August 2018
Our group has a new review paper, Dynamic balance of pro- and anti-inflammatory signals controls disease and limits pathology, published in Immunological Reviews.

May 2018
Check out Elsje's new paper, Emergence and selection of isoniazid and rifampin resistance in tuberculosis granulomas, published in PLoS ONE.

May 2018
Patrick passed his Doctoral Candidacy Exam, and Louis passed his Preliminary Exam. Congratulations on becoming PhD Candidates!

November 2017
Check out Phillip's new paper, The CXCL12/CXCR7 signaling axis, isoforms, circadian rhythms, and tumor cellular composition dictate gradients in tissue, published in PLoS ONE.

October 2017
At the 2017 Biomedical Engineering Society Annual Meeting in Phoenix, AZ, Bruna presented a poster on her research, and Joseph and Phillip had oral presentations.

October 2017
Patrick Kinnunen is new pre-doctoral candidate in our group. Welcome Patrick!

August 2017
Check out Joseph's new paper, Applying Optimization Algorithms to Tuberculosis Antibiotic Treatment Regimens, published in Cellular and Molecular Bioengineering.

August 2017
Dr. Elsje Pienaar is starting her new faculty position at the Weldon School of Biomedical Engineering at Purdue University. Check out her research webpage here. Congratulations!

July 2017
Two new postdoctoral scholars have joined our group: Dr. Caitlin Hult and Dr. Timothy Wessler. Welcome to Tim and Caitlin!

May 2017
A new bioinformatics graduate student, Louis Joslyn, has joined our group. Welcome Louis!

February 2017
Dr. Mohammad Fallahi-Sichani, a 2011 PhD alum from our group, is starting his faculty position in the BME department here at the University of Michigan. Welcome back Mohammad!

January 2017
Check out Madhuresh's new paper, New insights into mammalian signaling pathways using microfluidic pulsatile inputs and mathematical modeling , published in Integrative Biology.