The Linderman Research Group


department of chemical engineering @ the university of michigan

Laboratory for Quantitative Signaling and Multi-scale Modeling

Welcome to the Linderman Group webpage!
We apply chemical engineering principles to the field of biology and medicine. Our research is focused on fundamental studies in cell biology and cellular signal transduction, which has a myriad of applications including drug discovery and tissue engineering.

Research Areas


A multi-scale and multi-system approach to understand granuloma formation in TB	Models of receptor dynamics, signal transduction, and cell responses	Agent-based modeling of chemotaxis, drug distribution, and vascularization in the tumor microenvironment

Recent Media Coverage

We were featured by Michigan Engineering in an article titled Peering into the black box of tuberculosis!

Dr. Elsje Pienaar was featured in an article titled Fighting tuberculosis!

Recent News

October 2020
Congratulations to Dr. Joseph Cicchese on a successful thesis defense!

September 2020
Louis just published CaliPro: A Calibration Protocol That Utilizes Parameter Density Estimation to Explore Parameter Space and Calibrate Complex Biological Models in Cellular and Molecular Bioengineering!

August 2020
Congratulations to Caitlin for beginning an Assistant Professor role at Gettysburg College!

July 2020
Phillip and Patrick just published Pre-existing Cell States Control Heterogeneity of Both EGFR and CXCR4 Signaling in Cellular and Molecular Bioengineering!

May 2020

Congratulations to Celia for passing her doctoral candidacy exam!

Tim and Louis just published A computational model tracks whole-lung Mycobacterium tuberculosis infection and predicts factors that inhibit dissemination in Fronteirs in Pharmacology!

April 2020
U-M Women in Science and Engineering Program has awarded Bruna the 2020 Achievement Award, recognizing her leadership and ability to encourage others to achieve their goals! Congratulations Bruna!

March 2020
Joseph just published Both Pharmacokinetic Variability and Granuloma Heterogeneity Impact the Ability of the First-Line Antibiotics to Sterilize Tuberculosis Granulomas in Fronteirs in Pharmacology!

January 2020
Bruna just published An Agent-Based Systems Pharmacology Model of the Antibody-Drug Conjugate Kadcyla to Predict Efficacy of Different Dosing Regimens in The AAPS Journal!