Rhonda Jack, Khadijah Hussain, Danika Rodrigues, Mina Zeinali, Ebrahim Azizi, Max Wicha, Diane M. Simeone, and Sunitha Nagrath"Microfluidic continuum sorting of sub-populations of tumor cells via surface antibody expression levels." Lab on a Chip (2017).


Kathleen C Day*, Guadalupe Lorenzatti Hiles*, Molly Kozminsky*, Scott J Dawsey, Alyssa Paul, Luke J Broses, Rajal Shah, Lakshmi P Kunju, Christopher Hall, Nallasivam Palanisamy, Stephanie Daignault-Newton, Layla El-Sawy, Steven J Wilson, Andrew Chou, Kathleen M Ignatoski, Evan T. Keller, Dafydd G. Thomas, Sunitha Nagrath, Todd M. Morgan, and Mark L Day. "HER2 and EGFR overexpression support metastatic progression of prostate cancer to bone." Cancer Research (2017). *Denotes equal contribution



Sunitha Nagrath, Rhonda M. Jack, Vaibhav Sahai, and Diane M. Simeone. "Opportunities and Challenges for Pancreatic Circulating Tumor Cells." Gastroenterology 151.3 (2016): 412-426.


Molly Kozminsky and Sunitha Nagrath. "Circulating Tumor Cells, Cancer Stem Cells, and Emerging Microfluidic Detection Technologies with Clinical Applications." Cancer Stem Cells: Targeting the Roots of Cancer, Seeds of Metastasis, and Sources of Therapy Resistance. Elsevier New York, 2016. 473-497.


Zhuo Zhang, Hiroe Shiratsuchi, Nallasivam Palanisamy, Sunitha Nagrath, and Nithya Ramnath. "Expanded CTCs from a Patient with ALK Positive Lung Cancer Present EML4-ALK Rearrangement along with Resistance Mutation and Enable Drug Sensitivity Testing: A Case Study." Journal of Thoracic Oncology (2016). Temporary free link.


Vasudha Murlidhar*, Lianette Rivera-Baez*, and Sunitha Nagrath. "Affinity Versus Label-Free Isolation of Circulating Tumor Cells: Who Wins?" Small (2016). *Denotes equal contribution


Vasudha Murlidhar, Nithya Ramnath, Sunitha Nagrath, and Rishindra M. Reddy. "Optimizing the Detection of Circulating Markers to Aid in Early Lung Cancer Detection." Cancers 8.7 (2016): 61.


Meghna Waghray, Malica Yalamanchili, Michele Dziubinski, Mina Zeinali, Marguerite Erkkinen, Huibin Yang, Kara A. Schradle, Sumithra Urs, Marina Pasca Di Magliano, Theodore H. Welling, Phillip L. Palmbos, Ethan V. Abel, Vaibhav Sahai, Sunitha Nagrath, Lidong Wang, and Diane M. Simeone. "GM-CSF Mediates Mesenchymal-Epithelial Crosstalk in Pancreatic Cancer." Cancer Discovery (2016).


Yusuke Shiozawa, Janice E. Berry, Matthew R. Eber, Younghun Jung, Kenji Yumoto, Frank C. Cackowski, Hyeun Joong Yoon, Princy Parsana, Rohit Mehra, Jingcheng Wang, Samantha McGee, Eunsoh Lee, Sunitha Nagrath, Kenneth J. Pienta, Russell S. Taichman. "The marrow niche controls the cancer stem cell phenotype of disseminated prostate cancer." Oncotarget (2016).


Hyeun Joon Yoon*, Apoorv Shanker*, Yang Wang, Molly Kozminsky, Qu Jin, Nallasivam Palanisamy, Monika L. Burness, Ebrahim Azizi, Diane M. Simeone, Max S. Wicha, Jinsang Kim, and Sunitha Nagrath. "Tunable Thermal-Sensitive Polymer-Graphene Oxide Composite for Efficient Capture and Release of Viable Circulating Tumor Cells." Advanced Materials (2016). *Denotes equal contribution


Rhonda M. Jack, Meggie M. G. Grafton, Danika Rodrigues, Maria D. Giraldez, Catherine Griffith, Robert Cieslak, Mina Zeinali, Chandan Kumar Sinha, Ebrahim Azizi, Max Wicha, Muneesh Tewari, Diane M. Simeone, and Sunitha Nagrath. "Ultra-Specific Isolation of Circulating Tumor Cells Enables Rare-Cell RNA Profiling." Advanced Science.


Kozminsky, Molly, Yang Wang, and Sunitha Nagrath. "The incorporation of microfluidics into circulating tumor cell isolation for clinical applications." Current Opinion in Chemical Engineering 11 (2016): 59-66.


Azizi, Ebrahim, Sunitha Nagrath, Molly Kozminsky, and Max S. Wicha. "Cancer Stem Cells and Circulating Tumor Cells: Molecular Markers, Isolation Techniques, and Clinical Implications." Circulating Tumor Cells. Springer New York, 2016. 75-97.



Tam, Alda L., Howard J. Lim, Ignacio I. Wistuba, Anobel Tamrazi, Michael D. Kuo, Etay Ziv, Stephen Wong, Albert J. Shih, Robert J. Webster III, Gregory S. Fischer, Sunitha Nagrath, Suzanne E. Davis, Sarah B. White, Kamran Ahrar. "Image-Guided Biopsy in the Era of Personalized Cancer Care: Proceedings from the Society of Interventional Radiology Research Consensus Panel." Journal of Vascular and Interventional Radiology 27.1 (2016): 8-19.


Luo, Ming, Shawn G. Clouthier, Yadwinder Deol, Suling Liu, Sunitha Nagrath, Ebrahim Azizi, Max S. Wicha. "Breast cancer stem cells: current advances and clinical implications." Mammary Stem Cells: Methods and Protocols (2015): 1-49.


Reddy, Rishindra M., Vasudha Murlidhar, Lili Zhao, Svetlana Grabauskiene, Zhuo Zhang, Nithya Ramnath, Jules Lin, Andrew C. Chang, Phillip Carrott, William Lynch, Mark B. Orringer, David G. Beer, and Sunitha Nagrath. "Pulmonary venous blood sampling significantly increases the yield of circulating tumor cells in early-stage lung cancer." The Journal of thoracic and cardiovascular surgery (2015).


Zhang, Zhuo, Nithya Ramnath, and Sunitha Nagrath. "Current status of CTCs as liquid biopsy in lung cancer and future directions." Frontiers in oncology 5 (2015).


Heo, Yun Seok, Sunitha Nagrath, Alessandra L. Moore, Mahnaz Zeinali, Daniel Irimia, Shannon L. Stott, Thomas L. Toth, and Mehmet Toner. "'Universal' vitrification of cells by ultra-fast cooling." Technology 3.01 (2015): 64-71.



Kim, Tae Hyun, Hyeun Joong Yoon, Phillip Stella, and Sunitha Nagrath. "Cascaded spiral microfluidic device for deterministic and high purity continuous separation of circulating tumor cells." Biomicrofluidics 8.6 (2014): 064117.


Zhang, Zhuo, Hiroe Shiratsuchi, Jules Lin, Guoan Chen, Rishindra M. Reddy, Ebrahim Azizi, Shamileh Fouladdel, Andrew C. Chang, Lin Lin, Hui Jiang, Meghna Waghray, Gary Luker, Diane M. Simeone, Max S. Wicha, David G. Beer, Nithya Ramnath, and Sunitha Nagrath. "Expansion of CTCs from early stage lung cancer patients using a microfluidic co-culture model." Oncotarget 5, no. 23 (2014): 12383-12397.


Vasudha Murlidhar, Mina Zeinali, Svetlana Grabauskiene, Mostafa Ghannad-Rezaie, Max S. Wicha, Diane M. Simeone, Nithya Ramnath, Rishindra M. Reddy, and Sunitha Nagrath "A Radial Flow Microfluidic Device for Ultra-High-Throughput Affinity-Based Isolation of Circulating Tumor Cells." Small (2014).


Shailender Singh Kanwar, Christopher James Dunlay, Diane Simeone, and Sunitha Nagrath. "Microfluidic device (ExoChip) for On-Chip isolation, quantification and characterization of circulating exosomes." Lab on a Chip (2014).


Hyeun Joong Yoon*, Molly Kozminsky*, and Sunitha Nagrath. "Emerging Role of Nanomaterials in Circulating Tumor Cell Isolation and Analysis." ACS Nano (2014). *Equal contribution.



Hyeun Joong Yoon, Tae Hyun Kim, Zhuo Zhang, Ebrahim Azizi, Trinh M. Pham, Costanza Paoletti, Jules Lin, Nithya Ramnath, Max S. Wicha, Daniel F. Hayes, Diane M. Simeone & Sunitha Nagrath, “Sensitive capture of circulating tumour cells by functionalized graphene oxide nanosheets”, Nature Nanotechnology Vol 8. pp. 735-741 (2013)

Related features:
Nature Reviews Clinical Oncology, e! Science News, Nanowerk, EurekAlert!, Phys.org, Health Canal, Science Newsline, The Medical News, R&D, Science Daily, Medical News Today


Kanwar, Shailender Singh, Lianette Rivera, and Sunitha Nagrath. "Personalized Medicine through Circulating Tumor Cells: The New Dimension in Cancer Research." Journal of Developing Drugs (2013).


Kanwar S. S., Grafton M. M. G., and Nagrath S. (2013). Bio-MEMS (Microfluidics) for CTC Detection in Cancer Patients. In M. J. A. Shiddiky, E. J. H. Wee, S. Rauf and M. Trau (Eds.), Microfluidics, Nanotechnology and Disease Biomarkers for Personalized Medicine Applications (pp. 1-30). Hauppauge, NY: Nova Science Publishers ( ISBN: 978-1-62808-020-9)


Zhuo Zhang, S.Nagrath., “Microfluidics and cancer: are we there yet?”, Biomed Microdevices, Jan 2013



Stott, Shannon L., Chia-Hsien Hsu, Dina I. Tsukrov, Min Yu, David T. Miyamoto, Belinda A. Waltman, S. Michael Rothenberg, Ajay M. Shah, Malgorzata E. Smas, George K. Korir, Frederick P. Floyd, Jr., Anna J. Gilman, Jenna B. Lord, Daniel Winokur, Simeon Springer, Daniel Irimia, Sunitha Nagrath, Lecia V. Sequist, Richard J. Lee, Kurt J. Isselbacher, Shyamala Maheswaran, Daniel A. Haber, and Mehmet Toner. "Isolation of circulating tumor cells using a microvortex-generating herringbone-chip." Proceedings of the National Academy of Sciences 107.43 (2010): 18392-18397.


Stott, Shannon L.*, Richard J. Lee*, Sunitha Nagrath*, Min Yu, David T. Miyamoto, Lindsey Ulkus, Elizabeth J. Inserra, Matthew Ulman, Simeon Springer, Zev Nakamura, Alessandra L. Moore, Dina I. Tsukrov, Maria E. Kempner, Douglas M. Dahl, Chin-Lee Wu, A. John Iafrate, Matthew R. Smith, Ronald G. Tompkins, Lecia V. Sequist, Mehmet Toner, Daniel A. Haber, and Shyamala Maheswaran. "Isolation and characterization of circulating tumor cells from patients with localized and metastatic prostate cancer." Science translational medicine 2.25 (2010): 25ra23-25ra23.*Denotes equal contribution.



Russom, Aman, Amit K Gupta, Sunitha Nagrath, Dino Di Carlo, Jon F Edd and Mehmet Toner. "Differential inertial focusing of particles in curved low-aspect-ratio microchannels." New journal of physics 11.7 (2009): 075025.


Sequist, Lecia V., Sunitha Nagrath, Mehmet Toner, Daniel A. Haber, Thomas J. Lynch. "The CTC-chip: an exciting new tool to detect circulating tumor cells in lung cancer patients." Journal of Thoracic Oncology 4.3 (2009): 281-283.



Maheswaran S*, Sequist L*, Nagrath S*, Ulkus L, Brannigan B, Collura C, Inserra B, Diederichs S, Iafrate J, Digumarthy S, Muzikansky A, Irimia D, Settleman J, Tompkins R, Lynch T, Toner M, Haber DA, “Detecting Epidermal Growth Factor Receptor gene mutations in circulating tumor cells from patients with Non-Small Cell Lung Cancer”, New England Journal of Medicine 359(4), 366-377 (2008). *Equal contribution.



Nagrath, S*, Sequist, LV*, Maheswaran, S, Bell, DW, Irimia, D, Ulkus, L, Smith, MR, Kwak, EL, Digumarthy, S, Muzikansky, A, Ryan, P, Balis, UJ, Tompkins, RG, Haber, DA, Toner, M “Isolation of rare circulating tumour cells in cancer patients by microchip technology”, Nature: 450(20), 1235-1239 (2007). *Equal contribution.