Recent highlights

Tessier lab has three open postdoc positions and three open PhD positions related to protein engineering, antibody discovery and high-throughput antibody characterization (Aug 2017)

Tessier named the Albert M. Mattocks (Endowed) Professor of Pharmaceutical Sciences and Chemical Engineering at the University of Michigan (Aug 2017) [link]

Tessier lab moves to the University of Michigan (Aug 2017)

Lab discovers how antibodies overcome key affinity/stability trade-offs during affinity maturation (Scientific Reports, Mar 2017) [link]

Tessier co-chairs the 7th International Conference on Biomolecular Engineering (Jan 2017) [link]

Tessier presents the keynote lecture at RPI’s Trustee Celebration of Faculty Achievement (Dec 2016) [link]

Lab receives NSF grant to develop new antibody design and evolution methods (Aug 2016) [link]

Lab discovers a novel method for preparing stable antibody-gold conjugates and demonstrates their use in high-throughput screening applications (Aug 2016) [link]

Tessier promoted to Full Professor (Jul 2016) [link]

Tessier awarded the 2016 Biochemical Engineering Journal Young Investigator Award (Jun 2016) [link]

Lab reports a high-throughput method for assessing complex biophysical properties of therapeutic antibodies (Apr 2016) [link]

Lab discovers (in collaboration with the McNay lab at UAlbany) that their designed Alzheimer’s antibodies improve hippocampal signaling in rat models of diet-induced obesity (Mar 2016) [link]

Lab reports improved methods for designing anti-amyloid antibodies (Nov 2015) [link]

Lab reports a novel method for co-evolving antibody affinity and stability (Sept 2015) [link]

Lab discovers that highly soluble monoclonal antibodies can be identified prior to purification using a nanoparticle-based assay (Sept 2015) [link]

Lab published a review on Advances in Antibody Design in Annual Reviews in Biomedical Engineering

(Aug 2015) [link]

Tessier selected to participate in the 2015 U.S. National Academy of Engineering’s Frontiers of Engineering Symposium

(July 2015) [link]

Lab reports a nanoparticle screening method for detecting antibody aggregation in serum (Feb 2015) [link]

Tessier awarded the 2015 Biochemical Technology Young Investigator Award from the American Chemical Society (Dec 2014)

Tessier named one of 30 young scientists under the age of 40 to be honored at the World Economic Forum in Tianjin, China (Sept 2014) [link]

Tessier Lab

Design, evolution,   characterization & formulation of next generation biologics

Molecular Biotechnology

Our mission

The Tessier lab aims to develop next generation technologies for designing, discovering, engineering, characterizing, formulating and delivering biologics ranging from small affinity peptides to large monoclonal antibodies for molecular imaging, diagnostic and therapeutic applications. This interdisciplinary research program involves the use of experimental and computational approaches to generate new fundamental insights related to protein structure and function, molecular origins of protein-protein interactions, and sequence and structural determinants of key protein properties (stability, solubility, specificity and affinity). With an eye toward applications, the Tessier lab also develops novel high-throughput screening tools for discovering new biologics and identifying rare variants with drug-like properties for therapeutic applications.