Publications || Code

50. Thurber, G.M. Pharmacokinetic Considerations to Maximize an ADC’s Therapeutic Index. Journal of Antibody-Drug Conjugates. November 12, 2019. Link

48. Menezes, B.*, C. Cilliers*, T. Wessler, G.M. Thurber, and J. Linderman. An Agent-Based Systems Pharmacology Model of the Antibody Drug Conjugate Kadcyla to Predict Efficacy of Different Dosing Regimens. AAPS Journal. 2019, In Press

47. Singh, A., L. Guo, A. Verma, G. Wong, G.M. Thurber, and D. Shah. Antibody Coadministration as a Strategy to Overcome Binding-Site Barrier for ADCs: A Quantitative Investigation. AAPS Journal. 2019, In Press

46. Khera, E., L. Zhang, S. Roberts, I. Nessler, D. Sandoval, T. Reiner, and G.M. Thurber. Blocking Glucagon Like Peptide-1 Receptors in the Exocrine Pancreas Improves Specificity for Beta Cells in a Mouse Model of Type 1 Diabetes. Journal of Nuclear Medicine. 2019; 60: 1635-41. Link

45. Thurber, G.M. and R. Evans. Designing a disease screening pill: Challenges and opportunities in self-administration of optical probes. Proc. SPIE 10862, Molecular-Guided Surgery: Molecules, Devices, and Applications V, 108620G. 2019. Link

44. Bhatnagar, S.*, E. Khera*, J. Liao, V. Eniola, Y. Hu, D.E. Smith, and G.M. Thurber. Oral and Subcutaneous Administration of a Near-Infrared Fluorescent Imaging Agent Detects Inflammation in a Mouse Model of Rheumatoid Arthritis. Scientific Reports. 2019; 9(4661). Link

43. Atangcho, L., T. Navaratna, and G.M. Thurber. Hitting undruggable targets: viewing stabilized peptide development through the lens of quantitative systems pharmacology. Trends in Biochemical Sciences. 2019; 44(3): 241-57. Link

42. Khera, E., and G.M. Thurber. Pharmacokinetic and immunological considerations for expanding the therapeutic window of next-generation Antibody-Drug Conjugates. BioDrugs. 2018; 32(5): 465–80. Link

41. Bartelink, I., E. Jones, S. Shahidi-Latham, E. P. Rong, Y. Zheng, P. Vicini, L. vant Veer, D. Wolf, A. Iagaru, D. Kroetz, B. Prideaux, C. Cilliers, G. Thurber, Z. Wimana, and G. Gebhart. Tumor drug penetration measurements could be the neglected piece of the personalized cancer treatment puzzle. Clinical Pharmacology & Therapeutics. 2018; 106: 148-163. Link

40. Cilliers, C., and G.M. Thurber. "Standing by" for bystander effects: dual isotope imaging of Antibody-Drug Conjugates and payload distribution. Journal of Nuclear Medicine. 2018; 59(9): 1459-60. Link

39. Nessler, I., E. Khera, and G.M. Thurber. Quantitative pharmacology in antibody-drug conjugate development: armed antibodies or targeted small molecules? Oncoscience. 2018; 5(5-6): 161-3. PDF Link

38. Bhatnagar, S., K. Dhingra Verma, Y. Hu, E. Khera, A. Priluck, D. Smith, and G.M. Thurber. Oral administration and detection of a near-infrared molecular imaging agent in an orthotopic mouse model for breast cancer screening. Molecular Pharmaceutics. 2018; 5(5), pp 1746–54. Link

37. Cilliers, C., B. Menezes, I. Nessler, J. Linderman, and G.M. Thurber. Improved tumor penetration and single-cell targeting of antibody-drug conjugates increases anticancer efficacy and host survival. Cancer Research. 2017; 78(3): 758-68. Link

36. Khera*, E., C. Cilliers*, S. Bhatnagar, and G.M Thurber. Computational transport analysis of antibody-drug conjugate bystander effects and payload tumoral distribution: implications for therapy. Molecular Systems Design & Engineering. 2018; 3: 73-88. Link

35. Smith, A., M. Pawar, M.E. Van Dort, S. Galbán, A.R. Welton, G.M. Thurber, B.D. Ross, and C.G. Besirli. Ocular toxicity profile of ST-162 and ST-168 as novel bifunctional MEK/PI3K inhibitors. Journal of Ocular Pharmacology and Therapeutics. 2018; 34(6): 477-85. Link

34. Van Dort, M.E., S. Galbán, C.A. Nino, H. Hong, A.A. Apfelbaum, G.D. Luker, G.M. Thurber, L. Atangcho, C.G. Besirli, and B.D. Ross. Structure-guided design and initial studies of a bifunctional MEK/PI3K inhibitor (ST-168). ACS Medicinal Chemistry Letters. 2017; 8(8): 808–813. Link

33. Cilliers, C., I. Nessler, N. Christodolu, and G.M. Thurber. Tracking antibody distribution with near infrared fluorescent dyes: impact of dye structure and degree of labeling on plasma clearance. Molecular Pharmaceutics. 2017; 14(5): 1623-33. Link

32. Zhang, L., and G.M. ThurberImaging in Diabetes in Imaging and Metabolism. Springer, pp 175-197. Link

31. Zhang, L., T. Navaratna, and G.M. Thurber. A helix-stabilizing linker improves subcutaneous bioavailability of a helical peptide independent of inker lipophilicity. Bioconjugate Chemistry. 2016; 27(7): 1663–72. Link

30. Cilliers, C., H. Guo, J. Liao, N. Christodolu, and G.M. Thurber. Multiscale modeling of antibody-drug conjugates: connecting tissue and cellular distribution to whole animal pharmacokinetics and potential implications for efficacy. AAPS Journal. 2016; 18(5): 1117-30. Link

29. Zhang, L.*, S. Bhatnagar*, E. Deschenes, and G.M. Thurber. Mechanistic and quantitative insight into cell surface targeted molecular imaging agent design. Scientific Reports, 2016; 6 (25424). Link

28. Zhang, L. and G.M. Thurber. Quantitative Impact of Plasma Clearance and Down-regulation on GLP-1 Receptor Molecular Imaging. Molecular Imaging and Biology, 2016; 18(1): 79-89. Link 

27. G.M. Thurber. Tumor Effect-Site Pharmacokinetics: Mechanisms and impact on efficacy. In: Zhou, H and F.P Theil, editors. Application of ADME and Translational PK/PD in the Development of Therapeutic Biologics. Hoboken: John Wiley & Sons; 2015. pp. 225-40. Link 

26. Vinegoni, C., J.M. Dubach, G.M. Thurber, M.A. Miller, R. Mazitschek, and R. Weissleder. Advances in measuring single-cell pharmacokinetics and pharmacology in vivo. Drug Discovery Today, 2015; 20(9): 1087-92. Link 

25. Cilliers, C., J. Liao, L. Atangcho, and G.M. ThurberResidualization rates of near infrared dyes for the rational design of molecular imaging agents. Molecular Imaging and Biology. 2015; 17(6): 757-62. Link 

24. Zhang, L., T. Navaratna, J. Liao, and G.M. Thurber. A dual-purpose linker for alpha helix stabilization and imaging agent conjugation to glucagon-like Peptide-1 receptor ligands. Bioconjugate Chemistry. 2015; 26(2): 329-37. Link

23. Magnuson, A.M, G.M. Thurber, R.H Kohler, R. Weissleder, D. Mathis, and C. Benoist. Population dynamics of islet-infiltrating cells in autoimmune diabetes. Proc Natl Acad Sci U S A, 2015; 112(5):1511-16. Link

22. Cilfone, N., E. Pienaar, G.M. Thurber, D. Kirschner, and J. Linderman. A systems pharmacology approach towards the design of inhaled formulations of rifampicin and isoniazid for treatment of tuberculosis. CPT Pharmacometrics and Systems Pharmacology, 2015; 4(3): 193-203. Link

21. Bhatnagar, S., E. Deschenes, J. Liao, C. Cilliers, and G.M. Thurber. Multichannel imaging to quantify four classes of pharmacokinetic distribution in tumors. Journal of Pharmaceutical Sciences, 2014; 103(10): 3276-86. Link

Prior to the University of Michigan

20. Thurber, G.M., T. Reiner, K.S. Yang, R.H. Kohler, and R. Weissleder. Effect of small molecule modification on single cell pharmacokinetics of PARP inhibitors. Molecular Cancer Therapeutics 2014; 13(4): 986-95. Link

19. Thurber, G.M., K.S. Yang, T. Reiner, R.H. Kohler, P. Sorger, T. Mitchison, and R. Weissleder. Single-cell and subcellular pharmacokinetic imaging allows insight into drug action in vivo.  Nature Communications, 2013; 4: 1504. Link

18. Thurber, G.M. and K.D. Wittrup. A mechanistic compartmental model for antibody uptake in tumors. Journal of Theoretical Biology, 2012; 314: 57-68. Link

17. Feruglio P.F., C. Vinegoni, L. Fexon, G.M. Thurber, A. Sbarbati, R. Weissleder. Noise suppressed, multifocus image fusion for enhanced intraoperative navigation. Journal of Biophotonics, 2012. Link

16. Keliher, E.J., T. Reiner, G.M. Thurber, R. Upadhyay, R. Weissleder. Efficient 18F-Labeling of Synthetic Exendin-4 Analogues for Imaging Beta Cells. Chemistry Open, 2012. Link

15. Devaraj NK*, G.M. Thurber*, E.J. Keliher, B. Marinelli, R. Weissleder. Reactive Polymer Enables Efficient In Vivo Bioorthogonal Chemistry. Proc Natl Acad Sci U S A, 2012; 109(13): 4762-7. Link
* Denotes equal contribution

14. Wittrup K.D., G.M. Thurber, M.M. Schmidt, J.J. Rhoden. Practical Theoretic Guidance for the Design of Tumor Targeting Agents. Methods in Enzymology, 2012. 503: p. 255-268. Link

13. Thurber, G.M.*, R. Weissleder*, A Systems Approach for Tumor Pharmacokinetics. PLoS ONE, 2011; 6(9): e24696. Link
* Denotes corresponding authors

12. Reiner T., G.M. Thurber, J. Gaglia, et al. Accurate Measurement of Beta Cell Mass Using a Second-Generation Fluorescent Exendin-4 Analog. Proc Natl Acad Sci U S A, 2011; 108 (31): p. 12815-20. Link

11. Thurber G.M, Kinetics of Antibody Penetration into Tumors. In: Speer TW, editor. Targeted Radionuclide Therapy. Philadelphia: Lippincott Williams and Wilkins; 2011. p. 168-81.

10. Thurber, G.M. and R. Weissleder, Quantitating Antibody Uptake In Vivo: Conditional Dependence on Antigen Expression Levels. Molecular Imaging and Biology, 2011; 13 (4): p. 623. Link

9. Thurber, G.M., J.L. Figueiredo, R. Weissleder. Detection Limits of Intraoperative Near Infrared Imaging for Tumor Resection. Journal of Surgical Oncology, 2010; 102 (7): p. 758-64. Link

8. Thurber, G.M., J.L. Figueiredo, and R. Weissleder, Multicolor Fluorescent Intravital Live Microscopy (FILM) for Surgical Tumor Resection in a Mouse Xenograft Model. PLoS One, 2009. 4: 8053. Link

7. Nahrendorf, M., P. Waterman, G.M. Thurber, K. Groves, M. Rajopadhye, P. Panizzi, B Marinelli, E. Aikawa, M.J. Pittet, F.K. Swirski, and R. Weissleder. Hybrid in vivo FMT-CT imaging of protease activity in atherosclerosis with customized nanosensors. Arteriosclerosis, Thrombosis, and Vascular Biology, 2009. 29: 1444-51. Link

6. Devaraj, N.K., E.J. Keliher, G.M. Thurber, M. Nahrendorf, and R. Weissleder, 18F Labeled Nanoparticles for in vivo PET-CT Imaging. Bioconjugate Chemistry, 2009. 20: 397-01. Link

5. Schmidt, M.M., G.M. Thurber, and K.D. Wittrup, Kinetics of Anti-Carcinoembryonic Antigen Antibody Internalization: Effects of Affinity, Bivalency, and Stability. Cancer Immunology and Immunotherapy, 2008. 57: 1879-90. Link

4. Thurber, G.M., M.M. Schmidt, and K.D. Wittrup, Antibody tumor penetration: transport opposed by systemic and antigen-mediated clearance. Advanced Drug Delivery Reviews, 2008. 60: 1421-34. Link

3. Thurber, G.M. and K.D. Wittrup, Quantitative Spatiotemporal Analysis of Antibody Fragment Diffusion and Endocytic Consumption in Tumor Spheroids. Cancer Research, 2008. 68: 3334-41. Link

2. Thurber, G.M., M.M. Schmidt, and K.D. Wittrup, Factors Determining Antibody Distribution in Tumors. Trends in Pharmacological Sciences, 2008. 29(2): 57-61. Link

1. Thurber, G.M., S.C. Zajic, and K.D. Wittrup, Theoretic Criteria for Antibody Penetration into Solid Tumors and Micrometastases. Journal of Nuclear Medicine, 2007. 48(6): 995-99. Link