3D visualization of high-dimensional single-cell datasets
Our laboratory aims to engineer the function of protein assemblies, consisting of an array of complexed or non-complexed proteins, to solve problems in human health and sustainable energy.
Protein engineering, a relatively young field, has played a pivotal role in bringing biotechnology to the forefront of academic research and industrial practice. By focusing on the engineering of single target proteins, a great number of value-added natural and unnatural proteins have been successfully generated and commercialized, such as monoclonal antibodies, industrial enzymes, protein pharmaceuticals, etc. Looking forward to solve problems in more complex biological systems, our laboratory aims to engineer protein assemblies consisting of multiple proteins as a single entity to act in an orchestrated and synergistic manner to carry out specific and more sophisticated biological functions, such as immune-modulation and cascade catalysis. To meet our goals, the protein-assembly engineering must be in sync with an in-depth understanding of the biology underpinning individual problems. As such, our research program puts a balanced emphasis on both technology development and fundamental science. The key to our approach is thus highly interdisciplinary and involves state-of-the-art biology, chemistry, immunology, and biostatistics, with protein engineering principles (directed evolution and rational design) serving as the foundation.
Luke and Mason's paper "Engineering Spatially Organized Multi-enzyme Assemblies for Complex Chemical Transformation" was published in ACS Catalysis. Congrats!
Christine, Brett and Andrew's paper "The Coming Age of Insect Cells for Manufacturing and Development of Protein Therapeutics" was published in I&EC Research. Congrats!
Mason's paper on Protein-Scaffold Directed Nanoscale Assembly of T Cell Ligands was published in ACS Synthetic Biology. Congrats!
Prof. Wen was awarded the NSF CAREER Award. Read more
Brett and Andrew's paper "Engineering Virus-like Particles for Antigen and Drug Delivery" was published in Current Protein & Peptide Science.
Christine and Luke joined the Wen Lab as new PhD students. Welcome!
Prof. Wen was awarded funding by NSF/BME for immune profiling of T cells towards reproducible and scalable biomanufacturing process in personalized cancer immunotherapy
Prof. Wen's paper reporting her pedagogical research on active student learning was published in Chemical Engineering Education.
Hui's paper "Rare sugar production by coupling of NADH oxidase and L-arabinitol dehydrogenase" was published in RSC Advance.
Hui's paper "Immobilization of Multi-biocatalysts in Alginate Beads for Cofactor Regeneration and Improved Reusability" was published in Journal of Visualized Experiments.
Prof. Wen was awarded funding by NIH/ORIP for acquiring CyTOF (cytometry by time-of-flight) for investigating single cell proteomics
Mason and Andrew have been accepted to present their work at the AIChE Annual Meeting this year in San Francisco, CA. Congratulations!
Andrew Zak has received an honorable mention by the NSF. Congratulations Andrew!
Prof. Wen has been awarded CRLT's Investigating Student Learning Grant, 2016, funded by the Center for Research on Learning and Teaching, the Office of the Vice Provost for Global and Engaged Education, and the College of Engineering.
Andrew has joined the Wen Lab as new PhD students. Welcome!
Mason and Brett have successfully passed their prelim exam. Congratulations!
Mason and Brett have been accepted to present their work at the AIChE Annual Meeting this year in Salt Lake City, UT. Congratulations!
Prof. Wen was awarded funding by NIH/NCI to develop new antigen presentation systems and by NSF/BME to engineer protein assemblies for personalized cancer immunotherapy
Prof. Wen and her ChE342 undergraduate students welcomed 88 high school students in their classroom for their first-time U of M experience.
The Wen Lab has research opportunities for undergraduate and graduate students. Read more
Prof. Wen is developing outreach activities with the aims to foster engagement of K-12 students with UM undergraduate and graduate students.Read more