WEN GROUP
PROTEIN-ASSEMBLY ENGINEERING LAB




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May 2022

  • Our collaborative work with Dr. Sun's group titled "Albumin nanoparticle containing a PI3Kγ inhibitor and paclitaxel in combination with α-PD1 induces tumor remission of breast cancer in mice" has been published in Science Translational Medicine. Luke designed and performed the CyTOF experiment and conducted the data analysis. Read more

April 2022

  • Our collaborative work with Dr. Kahlenberg's group titled "Nonlesional lupus skin contributes to inflammatory education of myeloid cells and primes for cutaneous inflammation" has been published in Science Translational Medicine. Christine and Monem designed and performed the imaging CyTOF work. Read more

  • Trang has been awarded the highly competitive 2022 NSF Graduate Research Fellowship. Congratulations!

November 2021

  • Our collaborative work with Dr. Kahlenberg's group titled "B cell signatures distinguish cutaneous lupus erythematosus subtypes and the presence of systemic disease activity" has been published in Frontiers in Immunology. Christine and Monem designed and performed the imaging CyTOF work. Read more

October 2021

  • Bryan Coleman joined the Wen Lab as a new PhD student. Welcome!

June 2021

  • Xiao Yin, Brett and Trang's paper titled "Virus-inspired Strategies for Cancer Therapy" has been published in Seminars in Cancer Biology. Read more

March 2021

February 2021

  • Andrew, Luke and Xiao Yin's paper titled "Virtual versus In-Person Presentation as a Project Deliverable Differentially Impacts Student Engaged-Learning Outcomes in a Chemical Engineering Core Course" has been published in Journal of Chemical Education.Read more

January 2021

  • Our collaborative work with Dr. Zou's group titled "Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination" has been published in Nature Medicine. Monem designed and performed the CyTOF experiments. Read more

October 2020

  • Trang Hoang joined the Wen Lab as a new PhD student. Welcome!

  • Our collaborative work with Dr. Gudjonsson's group titled "Contribution of plasma cells and B cells to hidradenitis suppurativa pathogenesis" has been published in JCI Insight. Christine and Monem designed and performed the CyTOF experiments and analysis. Read more

September 2020

  • Xiao Yin has successfully passed her prelim exam. Congratulations!

  • Brett has successfully defended his thesis entitled "Development of a Yeast Biosynthetic Platform for Rapid Production and Engineering of an Influenza Virus-like Particle Vaccine". Congratulations, Dr. Hill!

July 2020

  • Our collaborative work with Dr. Kamada's group titled "The Intermucosal Connection between the Mouth and Gut in Commensal Pathobiont-Driven Colitis" has been published in Cell. Brett and Monem performed the CyTOF experiments and analysis. Read more

June 2020

  • Brett, Prabhu and Monem's paper titled "Yeast Intracellular Staining (yICS): Enabling High-throughput, Quantitative Detection of Intracellular Proteins via Flow Cytometry for Pathway Engineering" has been published in ACS Synthetic Biology. Read more

May 2020

  • Our COVID-19 research and vaccine development has been featured by the Michigan Engineering! Read More

November 2019

  • Luke and Andrew won the second place in the professional category of the AIChE k-12 STEM competition. Congratulations! Read more

September 2019

  • Our VLP work has been featured by the Michigan Engineering! Read More

  • Andrew, Brett, Monem, Mason and Maddie's paper titled "Enhancing the Yield and Quality of Influenza Virus-like Particles (VLPs) Produced in Insect Cells by Inhibiting Cytopathic Effects of Matrix Protein M2" has been published in ACS Synthetic Biology. Read more

  • Prof. Wen has been awarded the Young Alumni Achievement Award by the ChBE Department at the University of Illinois Urbana-Champaign. Read more

July 2019

  • Prof. Wen and Mason's work "Construction and Screening of an Antigen-Derived Peptide Library Displayed on Yeast Cell Surface for CD4+ T Cell Epitope Identification" has been published in Methods in Molecular Biology. Download PDF

  • Our work on whole-cell cooperative enzyme catalysis has been featured by the Michigan Engineering! Read more

  • Mason and Hui's paper "Elucidating structure–performance relationships in whole-cell cooperative enzyme catalysis" was published in Nature Catalysis. Congrats!

  • Andrew and Luke have been accepted to present their work at the AIChE Annual Meeting this year in Orlando, FL. Congratulations!

June 2019

  • Mason and Luke's paper "Rapid Microsphere Assisted Peptide Screening (MAPS) of Promiscuous MHCII‐Binding Peptides in Zika Virus Envelope Protein" was published in AIChE Journal. Congrats!

May 2019

  • Prof. Wen has been promoted to Associate Professor of Chemical Engineering.

  • Xiao Yin has successfully passed her Dissertation Candidacy Exam and become a PhD candidate. Congratulations, Xiao Yin!

April 2019

  • Our paper with the Gudjonsson group was published in JCI Insight. Download PDF

January 2019

  • Prof. Fei Wen has been awarded the UM College of Engineering David E. Liddle Research Excellence Award for 2018-2019. Read more

October 2018

  • Prof. Wen, Mason, Brett, Andrew and Christine presented their work at the AIChE Annual Meeting held in Pittsburgh, PA.

  • Xiao Yin joined the Wen Lab as a new PhD student. Welcome!

September 2018

  • Prof. Wen was named ACS Industrial & Engineering Chemistry Research's "2018 Class of Influential Researchers". Read more

  • Mason has successfully defended his thesis entitled "Quantitative Approach to Supramolecular Assembly Engineering for Isolating and Activating Antigen-Specific T Cells". Congratulations, Dr. Smith!

  • Christine has successfully passed her prelim exam. Congratulations!

  • Prof. Wen presented “A 40-parameter View of the Immune Landscape at Single-cell Resolution...and other Cool Things You Can Do With CyTOF” at the Taubman Technology Talks at the University of Michigan Frankel Cardiovascular Center.

August 2018

  • Luke has successfully passed his prelim exam. Congratulations!

July 2018

  • Christine, Brett and Andrew's paper "The Coming Age of Insect Cells for Manufacturing and Development of Protein Therapeutics" was published in I&EC Research. Congrats!

  • Luke and Mason's paper "Engineering Spatially Organized Multi-enzyme Assemblies for Complex Chemical Transformation" was published in ACS Catalysis. Congrats!

May 2018

  • Mason's paper on Protein-Scaffold Directed Nanoscale Assembly of T Cell Ligands was published in ACS Synthetic Biology. Congrats!

  • Luke and Christine have both successfully passed their Dissertation Candidacy Exam and become PhD candidates. Congratulations, Luke and Christine!

November 2017

  • Mason delivered a talk about his work on high throughput screening of antigenic peptides at the AIChE Annual Meeting.

September 2017

  • Our paper with the Larson group was published in the Journal of Computational Chemistry. Download PDF

March 2017

  • Luke has received an honorable mention by the NSF GRFP. Congratulations, Luke!

January 2017

  • Prof. Wen was awarded the NSF CAREER Award. Read more

November 2016

  • Brett and Andrew's paper "Engineering Virus-like Particles for Antigen and Drug Delivery" was published in Current Protein & Peptide Science. Download PDF

October 2016

  • Christine and Luke joined the Wen Lab as new PhD students. Welcome!

September 2016

  • Prof. Wen was awarded funding by NSF/BME for immune profiling of T cells towards reproducible and scalable biomanufacturing process in personalized cancer immunotherapy.

  • Prof. Wen was invited by NAE to present at the Frontiers of Engineering Education Symposium, Irvine, CA. Read more

August 2016

  • Prof. Wen's paper reporting her pedagogical research on active student learning was published in Chemical Engineering Education. Download PDF

July 2016

  • Hui's paper "Rare sugar production by coupling of NADH oxidase and L-arabinitol dehydrogenase" was published in RSC Advance. Download PDF

May 2016

  • Andrew has successfully passed his Dissertation Candidacy Exam and become a PhD candidate. Congratulations, Andrew!

April 2016

  • Hui's paper "Immobilization of Multi-biocatalysts in Alginate Beads for Cofactor Regeneration and Improved Reusability" was published in Journal of Visualized Experiments. Download PDF

March 2016

  • Prof. Wen was awarded funding by NIH/ORIP for acquiring CyTOF (cytometry by time-of-flight) for investigating single cell proteomics.

  • Prof. Wen was award the 2016 Provost's Teaching Innovation Prize. Read more

  • Andrew Zak has received an honorable mention by the NSF. Congratulations, Andrew!

November 2015

  • Prof. Wen has been awarded CRLT's Investigating Student Learning Grant, 2016, funded by the Center for Research on Learning and Teaching, the Office of the Vice Provost for Global and Engaged Education, and the College of Engineering.

October 2015

  • Andrew has joined the lab as a new PhD student. Welcome!

August 2015

  • Mason and Brett have successfully passed their prelim exam. Congratulations!

July 2015

  • Mason and Brett have been accepted to present their work at the AIChE Annual Meeting this year in Salt Lake City, UT. Congratulations!

June 2015

  • Prof. Wen was awarded funding by NSF/BME to engineer protein assemblies for personalized cancer immunotherapy.

May 2015

  • Congratulations to Eugene and Stephanie who completed their B.S. in Chemical Engineering! We wish you all the best with graduate school.

  • Congratulations to Deepika who completed her M.S. in Chemical Engineering! We wish you all the best with your new job at GSK in Pennsylvania.

  • Congratulations to Eshita who completed her M.S. in Biomedical Engineering!

April 2015

  • Eugene has been accepted into graduate school and will be attending Washington University, St. Louis for a PhD in Chemical Engineering. Congratulations, Eugene!

  • Stephanie has been accepted into graduate school and will be attending University of Illinois, Chicago for a PhD in Bioengineering. Congratulations, Stephanie!

February 2015

  • Lester, Mingcheng and Vicki joined the lab as undergraduate students. Welcome!

January 2015

  • Our paper with the Lee lab was published in the Biochemical Engineering Journal. Download PDF

  • Mason and Eshita’s review paper in Industrial and Engineering Chemistry Research is out. Congratulations! Download PDF

  • Alex Kukreja joined the Wen Group as a PIBS rotation student. Welcome!

December 2014

  • Prof. Wen was awarded funding by NIH/NCI to develop new antigen presentation systems for cancer immunotherapy.

  • Prof. Wen and her ChE342 undergraduate students welcomed 88 high school students in their classroom for their first-time U of M experience.

November 2014

  • Brett and Mason each presented a poster at the Annual Blue/Green Seminar hosted at Michigan State University.

  • Prof. Wen presented a talk titled “Dissection of Human T-cell Heterogeneity at Single-cell Resolution Using Mass Cytometry” at the AIChE Annual Meeting held in Atlanta, GA.

October 2014

  • Mason gave a talk at the 2014 MCubed Symposium titled "All in one detection of T cells: Specificity, Phenotype and Function"

September 2014

  • Joao Costa joined the Protein Assembly Engineering lab as a Master's student. Welcome Joe!

June 2014

  • Daniel has received a summer research internship in the Wen Research Group through the Summer Research Opportunity Program (SROP) at the University of Michigan. Congratulations and welcome, Dan!

May 2014

  • Eugene and Stephanie have received summer research internships through the Summer Undergraduate Research Experience (SURE) program at University of Michigan. Congratulations, Eugene and Stephanie!

  • Stephanie attended the 10th Annual PEGS meeting held in Boston, MA, to present a poster titled “A Robust System for Producing Large Panels of Human MHCII-peptide Complexes”.

  • Prof. Wen has been invited to present a talk titled “Engineering Protein Assemblies for Health and Energy” at the 18th Annual Conference of Chinese American Chemical Society, Great Lakes Chapter, Abbott Park, IL.

  • Mason and Brett have both successfully passed their Dissertation Candidacy Exam and become PhD candidates. Congratulations, Mason and Brett!

April 2014

  • Eugene has been awarded the A.H. White Scholarship. Congratulations, Eugene!

  • Eshita Khera joined the lab as a new Master's student. Welcome!

January 2014

  • Prof. Wen has been named the Dow Corning Assistant Professor of Chemical Engineering. Read more

  • Prof. Wen received an R03 grant from NIH/NIAID to develop new tools for multiplexed T-cell repertoire profiling.

  • Deepika has been awarded the Dow Sustainability Fellowship for the year 2014. Congratulations, Deepika!

December 2013

  • Syed Rizvi joined the lab as a Research Lab Specialist. Welcome!

November 2013

  • Prof. Wen presented a talk titled “Multiplexed Detection of T cells: A 40-parameter View of Single Cells” at the AIChE Annual Meeting held in San Francisco, CA.

October 2013

  • Mason Smith and Brett Hill joined the lab as new PhD students. Welcome!

  • Deepika Mutukuri joined the lab as a new Master's student. Welcome!

  • Prof. Wen has been invited to present a talk titled “Towards Multiplexed Single-cell Deep Immune Profiling: A 40-parameter View of Human Total T cells” in the Department of Microbiology & Immunology Seminar, University of Michigan.

September 2013

  • Galang Ramadhan and Eugene Kim joined the lab as undergraduate students.

August 2013

  • Prof. Wen received an instrument grant from the Office of Research and College of Engineering at UM.

May 2013

  • Stephanie Tolbert joined the lab as an undergraduate student. Welcome!

April 2013

  • Prof. Wen presented a poster at the Big 10 Women’s Workshop held in Milwaukee, WI.

February 2013

  • Prof. Wen’s project in collaboration with Dr. Ronald Larson and Timothy Johnson has been funded by MCubed at UM.

January 2013

  • Megan Egbert, Emily Carroll, and Evan Olexa joined the lab as undergraduate students. Welcome!

  • Prof. Wen has been invited to present a talk titled “Single-cell Deep Immune Profiling via CyTOF – The Next Generation of Cell Detection” at the Tumor Immunology & Host Response Program Meeting at the University of Michigan Comprehensive Cancer Center.

December 2012

  • Protein-Assembly Engineering Lab is established in Department of Chemical Engineering at UM.

October 2012

  • Cori Roth and Nathan Esperon joined the lab as new PhD students. Welcome!

September 2012

  • Prof. Wen joined the Department of Chemical Engineering at UM.

  • Veronica Weisman joined the lab for the semester as an undergraduate student. Welcome!

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© 2016 | Wen Group Protein-Assembly Engineering Lab. All Rights Reserved.
Created by Nehal Molasaria. Maintained by Christine Yee.