WEN GROUP
PROTEIN-ASSEMBLY ENGINEERING LAB






Prof. Fei Wen, PhD

Associate Professor, Department of Chemical Engineering
Office: NCRC B028-G058W | Lab: NCRC B028-G101E
Ph. No: (734) 764-8723 | Email: feiwenum@umich.edu
Professional Experience:

Associate Professor, University of Michigan, 2019 - Present
Dow Corning Assistant Professor, University of Michigan, 2014 - 2016
Assistant Professor, Chemical Engineering, University of Michigan, 2012 - 2019
Post Doctoral Researcher, Stanford University, 2010 - 2012

Education:
PhD Chemical and Biomolecular Engineering - 2010, University of Illinois Urbana-Champaign, Advisor: Huimin Zhao
MS Chemical Engineering - 2006, University of Illinois Urbana-Champaign
BS Chemical Engineering - 2003, Tsinghua University, Beijing, China


Syed Monem Rizvi

Research Lab Specialist, Department of Chemical Engineering
Research Investigator, Department of Microbiology and Immunology, University of Michigan
PhD, University of Cambridge, UK


smrizvi@umich.edu

My research is focused on the development of influenza virus like particles using yeast cells and in engineering yeast cells that are capable of converting lignocellulosic biomass to alternative biofuels.

Prabhu Ponnandy

Postdoctoral Scholar, Department of Chemical Engineering
Postdoctoral Research Fellow, Department of Pathology and Immunology, The Hebrew University-Hadassah Medical School, Jerusalem, Israel
PhD, Konkuk University, Seoul, Korea


prabhup@umich.edu

Bioethanol is widely considered as an alternative to conventional non-renewable fossil fuels. My research project focuses on the production of Bioethanol from Metabolic Engineered yeast cells.

Brett Hill

PhD Chemical Engineering, University of Michigan
B.S. Chemical Engineering, Colorado State University


labrett@umich.edu

Virus-like particles represent the structure of a virus but lack the genetic material that allows viruses to reproduce. Their lack of a genome makes them excellent candidates for vaccines as they pose no risk of infection, but they accurately represent the antigenic surface proteins that elicit antibody production. The aim of my research is to design a high-throughput process for producing multi-protein virus-like particles.

Andrew Zak

Graduate Student, PhD Candidate, Department of Chemical Engineering
B.S. Chemical Engineering, Cleveland State University

zaka@umich.edu

My research project is focused on understanding the immune response of T cells to virus-like particles with different biomolecular designs (i.e. different flu strains or protein mutations). This work will allow for the production of more highly effective vaccines and may lead to the development of a universal influenza vaccine.

Luke Bugada

Graduate Student, PhD Candidate, Department of Chemical Engineering
B.C.E. Chemical Engineering, University of Dayton

lfbugada@umich.edu

Artificial antigen presentation systems (aAPS) mimic the process through which an immune response is generated and have the potential to treat a host of illnesses that involve the immune system such as infectious diseases, cancer, and autoimmune disorders. My project involves engineering protein scaffolds so they can selectively arrange multiple proteins for use in aAPS.

Christine Yee

Graduate Student, PhD Candidate, Department of Chemical Engineering
B.S. Chemical and Biomolecular Engineering, Georgia Institute of Technology

cmyee@umich.edu

My research focuses on the genome editing of insect cells to be used as an alternative host for manufacturing protein-based therapeutics.

Xiao Yin Ma

Graduate Student, PhD Candidate, Department of Chemical Engineering
B.S. Chemical and Biomolecular Engineering, Cornell University

maxy@umich.edu

My research focuses on developing quantitative approaches to engineer cellulosomes in yeasts to produce biofuels.

Trang Hoang

Graduate Student, PhD Candidate, Department of Chemical Engineering
B.S. Chemical Engineering, Iowa State University

trhoang@umich.edu

My research focuses on immune profiling using CyTOF. This work will provide further understanding of the immune system that can contribute to the study of cancer immunology and immunoengineering.

Mukai Wang

Graduate Student, PhD Candidate, Department of Biostatistics
M.S. Biostatistics, University of Michigan
B.S.E. Data Science, University of Michigan
B.S.E. Electrical and Computer Engineering, Shanghai Jiao Tong University


wangmk@umich.edu

I offer quantitative analysis and software development support for the lab. Currently I am working on image segmentation and single cell clustering for image CyTOF data.

Bryan Coleman

Graduate Student, PhD Pre-Candidate, Department of Chemical Engineering
B.S. Chemical Engineering, Texas A&M University

brycol@umich.edu

Protein and cellular engineering for sustainable production of biofuels and biochemicals

Saiful Roslan

Research Assistant, Department of Chemical Engineering
B.S.E Chemical Engineering, University of Michigan – Ann Arbor

saifulbr@umich.edu

Virosome is a reconstituted nanovesicles containing immunogens that resembles the morphology of a virus but lacks its genetic material. My research focuses on engineering influenza virosome with high antigen density that can be used as a potential vaccine candidate.

Sanjeev Raja

Undergraduate (Junior) Student, Department of Chemical Engineering

sanjeevr@umich.edu

Time-of-flight mass cytometry (CyTOF) enables high-throughput, deep phenotyping of immune cells at the single-cell level. My research focuses on developing and using computational, statistical, and machine learning techniques to analyze high-dimensional CyTOF data, with the goal of uncovering the biological mechanisms and subpopulations of interest in the immune response to influenza and other diseases.

Current Members




ALUMNI


Madison Bonahoom

Undergraduate Student, 2019-2020
Current Position:

Marisa Patel

Undergraduate Student, 2019-2020
Current Position: Undergraduate Student, University of Michigan

Brian Yam

Undergraduate Student, 2019-2020
Current Position: Undergraduate Student, University of Michigan

Nicholas Ontko

Undergraduate Student, 2019-2020
Current Position: Undergraduate Student, University of Michigan

Reid Bailey

Undergraduate Student, 2019-2020
Current Position: SC Johnson

Mason Smith

Graduate Student, 2013-2018
Current Position: Systems Design Engineer, Advanced Technology Research at Thermo Fisher Scientific

Hui Gao

Visiting Scholar, Graduate Student, 2015-2018
Current Position:

Lester Lee

Undergraduate Student, 2015-2017
Current Position: Piping engineer at Vancouver Shipyards

Mingcheng Yi

Undergraduate Student, 2015-2017
Current Position: Master's Student, Stanford University

Vicki Chung

Undergraduate Student, 2015-2017
Current Position: Analytics Consultant (Big Data) at Rakuten, Inc.

Eshita Khera

Master's Student, 2014-2015
Current Position: Graduate Student, University of Michigan

Eugene Kim

Undergraduate Student, 2014-2015
Current Position: Graduate Student, Washington University, St. Louis

Stephanie Tolbert

Undergraduate Student, 2013-2015
Current Position: Graduate Student, University of Illinois Chicago

Deepika Mutukuri

Master's Student, 2013-2015
Current Position: Process Engineer at GlaxoSmithKline

Joao Costa

Master's Student, 2014
Current Position: Operations Engineer at BASF

Daniel Quevedo

Visiting Undergraduate Student, University of Miami, 2014
Current Position: Fulbright Fellow, Karlsruhe Institute of Technology

Cori Roth

Master's Student, 2012-2013
Current Position: Systems Integration Analyst at Accenture

Nathan Esperon

Master's Student, 2012-2013
Current Position: Graduate Student, Pennsylvania State University

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